SCHEMBL28348126

SCHEMBL28348126

CCc1ccc(-c2ccc3c(Oc4ccccc4)csc3c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
MAPT P10636 2/20 0.38
PKM P14618 1/20 0.38
TTR P02766 2/20 0.36
ICAM1 P05362 1/20 0.35
SELE P16581 1/20 0.35
VCAM1 P19320 1/20 0.35
ESR1 P03372 1/20 0.35
MAPKAPK2 P49137 1/20 0.34
TP53 P04637 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HSD17B10 Q99714 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33
ADORA1 P30542 1/20 0.33
ADRB1 P08588 1/20 0.32
ADRB3 P13945 1/20 0.32
MAP3K8 P41279 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28351542 0.87 MAP3K8 (0.39) NPC1RAB9AICAM1SELEVCAM1
SCHEMBL28348631 0.87 HSD11B1 (0.40) MAPTICAM1SELEALDH1A1
SCHEMBL28351620 0.86 RARB (0.41) MAPTICAM1SELEALDH1A1
SCHEMBL28352075 0.86 RARB (0.41) MAPTICAM1SELEALDH1A1
SCHEMBL28348408 0.86 RARB (0.41) MAPTICAM1SELEALDH1A1
SCHEMBL28348622 0.86 RARB (0.41) MAPTICAM1SELEALDH1A1
SCHEMBL28348588 0.86 RARB (0.41) MAPTICAM1SELEALDH1A1
SCHEMBL28348158 0.75 ESR1 (0.38) NPC1RAB9AMAPTPKMESR1
SCHEMBL28348703 0.74 RAB9A (0.36) NPC1RAB9AMAPTMAPKAPK2TP53
SCHEMBL13437634 0.73 LTA4H (0.55) RAB9ATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110734452-A semiconductor materials, and preparation method and application thereof 北京大学深圳研究生院 2020-01-31 CN disclosed