Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28345018 | 0.88 | LMNA (0.51) | LMNAMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL28348535 | 0.88 | TP53 (0.42) | LMNAMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL28350646 | 0.85 | KMT2A (0.43) | KDM4ETDP1POLBL3MBTL1DHODH | |
| SCHEMBL28345856 | 0.84 | LMNA (0.51) | LMNAMAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL973238 | 0.81 | ATM (0.47) | DHODH | |
| SCHEMBL972255 | 0.81 | EGFR (0.48) | SMN1; SMN2DHODH | |
| SCHEMBL22029397 | 0.81 | POLB (0.47) | MAPTKDM4ESMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL19186 | 0.80 | JMJD6 (0.44) | LMNAKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL3685890 | 0.78 | HTT (0.43) | LMNAKDM4ERAB9ATP53HTT | |
| SCHEMBL28348547 | 0.78 | NPSR1 (0.42) | LMNAMAPTKDM4ESMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110615765-B | (1H-pyrazole-4-formamido) ethyl benzoate compound and preparation method and application thereof | 浙江工业大学 | 2021-06-25 | — | — | CN | disclosed |
| CN-110615765-A | (1H-pyrazole-4-formamido) ethyl benzoate compound and preparation method and application thereof | 浙江工业大学 | 2019-12-27 | — | — | CN | disclosed |