Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31265247 | 0.91 | TSHR (0.41) | JMJD6ADORA3ADORA2AADORA1TSHR | |
| SCHEMBL31265255 | 0.90 | JMJD6 (0.41) | JMJD6TSHRBAZ2BBAZ2AHSD17B10 | |
| SCHEMBL439677 | 0.89 | TSHR (0.38) | JMJD6ADORA3ADORA2AADORA1TSHR | |
| SCHEMBL963986 | 0.88 | BAZ2B (0.43) | JMJD6ADORA3ADORA2AADORA1TSHR | |
| SCHEMBL862681 | 0.86 | ADORA3 (0.45) | JMJD6ADORA3ADORA2AADORA1TSHR | |
| SCHEMBL1862734 | 0.85 | KDM4E (0.43) | JMJD6ADORA3ADORA2AADORA1TSHR | |
| SCHEMBL16892760 | 0.85 | TSHR (0.41) | JMJD6TSHRBAZ2BBAZ2AHSD17B10 | |
| SCHEMBL8786300 | 0.85 | TSHR (0.41) | JMJD6ADORA3ADORA2AADORA1TSHR | |
| SCHEMBL21126224 | 0.85 | TSHR (0.42) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL28363345 | 0.85 | ALDH1A1 (0.36) | JMJD6ADORA3ADORA2AADORA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 400 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119823044-A | Preparation method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester | 湖南化工研究院有限公司 | 2025-04-15 | — | — | CN | claimed |
| CN-119504588-A | Preparation method of fluorine-containing pyrazole derivative | 多氟多新材料股份有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-115819346-B | Synthesis method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-ethyl formate | 湖南化工研究院有限公司 | 2024-09-24 | — | — | CN | claimed |
| CN-118055036-A | Link prediction method and device based on network evolution mechanism | 电子科技大学 | 2024-05-17 | — | — | CN | claimed |
| CN-114957123-B | 3- (difluoromethyl) -pyrazole-4-carboxylic ester derivative and preparation method and application thereof | 浙江工业大学 | 2023-11-28 | — | — | CN | claimed |
| CN-116178265-A | Synthesis method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid | 常州工程职业技术学院 | 2023-05-30 | — | — | CN | claimed |
| CN-116023331-A | Synthesis method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid | 馨仝(上海)生物科技有限公司 | 2023-04-28 | — | — | CN | claimed |
| CN-115819346-A | Synthetic method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-ethyl formate | 湖南化工研究院有限公司 | 2023-03-21 | — | — | CN | claimed |
| CN-114644744-A | Fluorine functional group covalent organic framework material, preparation method and application | 郑州大学第一附属医院 | 2022-06-21 | — | — | CN | claimed |
| CN-114195678-A | Intermediate, preparation method thereof and method for preparing 3-difluoromethyl-1-methylpyrazole-4-ethyl formate by using intermediate | 江苏七洲绿色科技研究院有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-111233768-A | Preparation method of 3- (difluoromethyl) -1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester | 徐州圣元化工有限公司 | 2020-06-05 | — | — | CN | claimed |
| CN-105218448-B | A kind of synthetic method of the pyrazole carboxylic acid of 1 methyl, 3 difluoromethyl 4 | 江苏恒润制药有限公司 | 2017-11-07 | — | — | CN | claimed |
| EP-2560961-B1 | METHOD FOR PRODUCING 5-FLUOR-1-ALKYL-3-FLUOROALKYL-1H-PYRAZOL-4-CARBOXYLIC ACID AND CHLORIDES AND FLUORIDES | BAYER IP GMBH (DE) | 2016-11-16 | — | — | EP | claimed |
| CN-105218448-A | A kind of synthetic method of 1-methyl-3-difluoromethyl-4-pyrazole carboxylic acid | Jiangsu hengrun pharmaceutical co ltd | 2016-01-06 | — | — | CN | claimed |
| WO-2015155713-A1 | PROCESS FOR THE REGIOSELECTIVE SYNTHESIS OF 1,3, 4 -SUBSTITUTED PYRAZOLES | ISAGRO S.P.A. (IT) | 2015-10-15 | — | — | WO | claimed |
| EP-2671873-A1 | Method for the cyclization of hydrazinoacrylic acid derivatives | SOLVAY SA (BE) | 2013-12-11 | — | — | EP | claimed |
| US-8431718-B2 | Process for the preparation of 5-fluoro-1-alkyl-3-fluoroalky1-1H-pyrazole-4-carbonyl chlorides and fluorides | BAYER CROPSCIENCE AG (DE) | 2013-04-30 | — | — | US | claimed |
| EP-2560961-A1 | PROCESS FOR PREPARING 5-FLUORO-1-ALKYL-3-FLUOROALKYL-1H-PYRAZOLE-4-CARBONYL CHLORIDES AND FLUORIDES | Bayer Intellectual Property GmbH (DE) | 2013-02-27 | — | — | EP | claimed |
| US-20110288305-A1 | Process for the preparation of 5-Fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl Chlorides and Fluorides | BAYER CROPSCIENCE AG (DE) | 2011-11-24 | — | — | US | claimed |
| WO-2011131615-A1 | PROCESS FOR PREPARING 5-FLUORO-1-ALKYL-3-FLUOROALKYL-1H-PYRAZOLE-4-CARBONYL CHLORIDES AND FLUORIDES | BAYER CROPSCIENCE AG (DE) | 2011-10-27 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288305-A1 | Process for the preparation of 5-Fluoro-1-alkyl-3-fluoroalkyl-1H-pyrazole-4-carbonyl Chlorides and Fluorides | AFF4, AFF1, FLI1 | JMJD6 1488/4885ADORA3 3268/4885ADORA2A 4715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.