SCHEMBL972255

SCHEMBL972255

Cn1cc(C(=O)Nc2c(F)cccc2Cl)c(C(F)F)n1

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.48
DHODH Q02127 16/20 0.48
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28350646 0.86 KMT2A (0.43) EGFRDHODH
SCHEMBL973238 0.86 ATM (0.47) EGFRDHODH
SCHEMBL868026 0.84 EGFR (0.40) EGFRDHODHSMN1; SMN2
SCHEMBL16212684 0.84 EGFR (0.40) EGFRDHODHSMN1; SMN2
SCHEMBL1145148 0.84 CHRNA7 (0.43) EGFRDHODH
SCHEMBL974151 0.83 CYP1A2 (0.51) SMN1; SMN2
SCHEMBL3685890 0.83 HTT (0.43) DHODH
SCHEMBL22029397 0.83 POLB (0.47) DHODHSMN1; SMN2
SCHEMBL973770 0.82 LMNA (0.62) EGFRDHODHSMN1; SMN2
SCHEMBL28348449 0.81 LMNA (0.48) DHODHSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2257530-B1 PROCESS FOR PREPARING SUBSTITUTED BIPHENYLANILIDES BAYER CROPSCIENCE AG (DE) 2011-10-12 EP disclosed
US-20110003999-A1 Process for Preparing Substituted Biphenylanilides BAYER CROPSCIENCE AG (DE) 2011-01-06 US disclosed
EP-2257530-A1 PROCESS FOR PREPARING SUBSTITUTED BIPHENYLANILIDES Bayer CropScience Aktiengesellschaft (DE) 2010-12-08 EP disclosed
WO-2009106234-A1 PROCESS FOR PREPARING SUBSTITUTED BIPHENYLANILIDES BAYER CROPSCIENCE AG (DE) 2009-09-03 WO disclosed
EP-2093216-A1 Process for preparing substituted biphenylanilides Bayer CropScience AG (DE) 2009-08-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110003999-A1 Process for Preparing Substituted Biphenylanilides DDT, PAH, THOP1 EGFR 1182/4885DHODH 78/4885SMN1; SMN2 3795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.