Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | PON1 | P27169 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869646 | 0.98 | NPSR1 (0.51) | NPSR1SMN1; SMN2MEN1APAF1NPC1 | |
| Hydrochloric Acid SCHEMBL1880315 | 0.97 | NPSR1 (0.50) | NPSR1SMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL12558221 | 0.94 | NPSR1 (0.54) | NPSR1SMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL2832102 | 0.92 | NPSR1 (0.46) | NPSR1SMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL21314161 | 0.92 | NPSR1 (0.46) | NPSR1SMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL21314159 | 0.89 | MAPT (0.43) | NPSR1SMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL925001 | 0.88 | KMT2A (0.46) | NPSR1SMN1; SMN2MEN1APAF1NPC1 | |
| Hydrochloric Acid SCHEMBL8137482 | 0.87 | KMT2A (0.45) | NPSR1SMN1; SMN2MEN1APAF1NPC1 | |
| Trifluoromethanesulfonic Acid SCHEMBL2830949 | 0.84 | NPSR1 (0.40) | NPSR1SMN1; SMN2MEN1APAF1NPC1 | |
| Bromide SCHEMBL9661601 | 0.82 | MAPT (0.49) | NPSR1SMN1; SMN2MEN1APAF1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048327-A1 | Highly-Neutralized Golf Ball Compositions | ACUSHNET COMPANY | 2010-02-25 | — | — | US | disclosed |
| WO-2007107152-A2 | DEPOSITION OF NANOSCALE METALS, SEMIMETALS AND COMPOUNDS OF SAID METALS AND/OR SEMIMETALS ON THE BOUNDARY SURFACE BETWEEN A LOW TEMPERATURE DISCHARGE AND AN IONIC LIQUID | JUSTUS-LIEBIG-UNIVERSITÄT GIESSEN (DE) | 2007-09-27 | — | — | WO | disclosed |