Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | PON1 | P27169 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL925001 | 0.98 | KMT2A (0.46) | KMT2ASMN1; SMN2MEN1APAF1NPC1 | |
| Hydrochloric Acid SCHEMBL1880315 | 0.90 | NPSR1 (0.50) | KMT2ASMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL869646 | 0.88 | NPSR1 (0.51) | KMT2ASMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL12558221 | 0.87 | NPSR1 (0.54) | KMT2ASMN1; SMN2MEN1APAF1NPC1 | |
| Bromide SCHEMBL2835015 | 0.87 | NPSR1 (0.54) | KMT2ASMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL21314161 | 0.83 | NPSR1 (0.46) | KMT2ASMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL2832102 | 0.83 | NPSR1 (0.46) | KMT2ASMN1; SMN2MEN1APAF1NPC1 | |
| Hydrochloric Acid SCHEMBL383000 | 0.82 | PON1 (0.52) | KMT2ASMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL924656 | 0.81 | BCHE (0.37) | KMT2ASMN1; SMN2MEN1APAF1NPC1 | |
| SCHEMBL667065 | 0.80 | PON1 (0.50) | KMT2ASMN1; SMN2MEN1APAF1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025496-A | Process for preparing heterocyclic carbenes | CELANESE GMBH (DE) | 2000-02-15 | — | — | US | disclosed |