Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 13/20 | 0.73 |
| ▸ | KDR | P35968 | 8/20 | 0.70 |
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | EGFR | P00533 | 6/20 | 0.68 |
| ▸ | RET | P07949 | 2/20 | 0.65 |
| ▸ | KIF5B | P33176 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 2/20 | 0.65 |
| ▸ | CIT | O14578 | 1/20 | 0.65 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.65 |
| ▸ | STK17B | O94768 | 1/20 | 0.65 |
| ▸ | STK10 | O94804 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28354714 | 1.00 | SRC (0.73) | SRCKDRAURKAEGFRRET | |
| SCHEMBL28350781 | 0.90 | EGFR (0.76) | SRCKDREGFRRETFLT4 | |
| SCHEMBL28350501 | 0.90 | EGFR (0.76) | SRCKDREGFRRETFLT4 | |
| SCHEMBL28350751 | 0.88 | SRC (0.77) | SRCKDRAURKAEGFR | |
| SCHEMBL28882352 | 0.87 | SRC (0.77) | SRCKDRAURKAEGFRRET | |
| SCHEMBL28354676 | 0.87 | SRC (0.77) | SRCKDRAURKAEGFRRET | |
| SCHEMBL13529060 | 0.85 | SRC (0.84) | SRCKDRAURKAEGFRRET | |
| SCHEMBL28354308 | 0.85 | SRC (0.77) | SRCKDRAURKAEGFRRET | |
| SCHEMBL28350517 | 0.85 | SRC (0.77) | SRCKDRAURKAEGFRRET | |
| SCHEMBL19154598 | 0.85 | SRC (0.80) | SRCKDRAURKAEGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110746398-A | 4-heterocyclic substituted quinazoline derivative and preparation method and application thereof | 刘沛友 | 2020-02-04 | — | — | CN | disclosed |