Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28351501 | 0.94 | POLB (0.50) | CFTRKMT2ARAB9ANPC1MAPK1 | |
| SCHEMBL28351731 | 0.85 | CFTR (0.51) | CFTRKMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28351327 | 0.82 | KDM4E (0.47) | KMT2ARAB9ANPC1MAPK1SMN1; SMN2 | |
| SCHEMBL28354910 | 0.81 | LRRK2 (0.48) | KMT2ARAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL28355007 | 0.81 | MAPT (0.49) | CFTRKMT2ARAB9ANPC1MAPK1 | |
| SCHEMBL28351642 | 0.81 | CFTR (0.50) | CFTRKMT2AGAAMAPTTP53 | |
| SCHEMBL28354958 | 0.78 | PAK4 (0.49) | KMT2A | |
| SCHEMBL28355134 | 0.76 | POLB (0.48) | KMT2ARAB9ANPC1MAPK1SMN1; SMN2 | |
| SCHEMBL28351398 | 0.75 | PDE4A (0.48) | RAB9ANPC1MAPK1MAPT | |
| SCHEMBL28351430 | 0.75 | PDE4A (0.48) | RAB9ANPC1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | claimed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | claimed |
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | disclosed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | disclosed |