Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | BRD4 | O60885 | 5/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28351398 | 0.98 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL28355007 | 0.93 | MAPT (0.49) | PDE4APDE4BPDE4CPDE4DLRRK2 | |
| SCHEMBL28355027 | 0.89 | BRD4 (0.49) | BRD4LRRK2PAK4MAPK8TYRO3 | |
| SCHEMBL28351335 | 0.87 | PAK4 (0.50) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28351642 | 0.84 | CFTR (0.50) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL28351327 | 0.83 | KDM4E (0.47) | BRD4LRRK2PAK4MAPK8TYRO3 | |
| SCHEMBL28354910 | 0.82 | LRRK2 (0.48) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28351731 | 0.81 | CFTR (0.51) | PDE4APDE4BPDE4CPDE4DCLK4 | |
| SCHEMBL28351501 | 0.80 | POLB (0.50) | BRD4MAPK1NPC1RAB9A | |
| SCHEMBL28351033 | 0.79 | KMT2A (0.47) | BRD4MAPTALDH1A1PDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | claimed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | claimed |
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | disclosed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | disclosed |