Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 8/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28351430 | 0.98 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL28355007 | 0.93 | MAPT (0.49) | PDE4APDE4BPDE4CPDE4DLRRK2 | |
| SCHEMBL28355027 | 0.89 | BRD4 (0.49) | BRD4LRRK2PAK4MAPK8TYRO3 | |
| SCHEMBL28351642 | 0.86 | CFTR (0.50) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL28351335 | 0.85 | PAK4 (0.50) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28351327 | 0.85 | KDM4E (0.47) | BRD4LRRK2PAK4MAPK8TYRO3 | |
| SCHEMBL28354910 | 0.82 | LRRK2 (0.48) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28351501 | 0.82 | POLB (0.50) | BRD4MAPK1NPC1RAB9A | |
| SCHEMBL28351033 | 0.81 | KMT2A (0.47) | BRD4HDAC3HDAC1ALDH1A1MAPT | |
| SCHEMBL28351731 | 0.81 | CFTR (0.51) | PDE4APDE4BPDE4CPDE4DCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | claimed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | claimed |
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | disclosed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | disclosed |