Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28355007 | 0.89 | MAPT (0.49) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28354958 | 0.86 | PAK4 (0.49) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28351335 | 0.83 | PAK4 (0.50) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28351327 | 0.83 | KDM4E (0.47) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28351430 | 0.82 | PDE4A (0.48) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28351398 | 0.82 | PDE4A (0.48) | LRRK2PAK4MAPK8TYRO3CLK4 | |
| SCHEMBL28351005 | 0.81 | CFTR (0.51) | NPC1RAB9AKMT2ASMN1; SMN2LMNA | |
| SCHEMBL28351731 | 0.79 | CFTR (0.51) | CLK4NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL28355134 | 0.78 | POLB (0.48) | NPC1RAB9ANPSR1CTDSP1KMT2A | |
| SCHEMBL28355027 | 0.77 | BRD4 (0.49) | LRRK2PAK4MAPK8TYRO3CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | claimed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | claimed |
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | disclosed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | disclosed |