Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | RHOC | P08134 | 1/20 | 0.45 |
| ▸ | RHOA | P61586 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28351430 | 0.87 | PDE4A (0.48) | PAK4MAPK8TYRO3LRRK2CLK4 | |
| SCHEMBL28351398 | 0.85 | PDE4A (0.48) | PAK4MAPK8TYRO3LRRK2CLK4 | |
| SCHEMBL28354910 | 0.83 | LRRK2 (0.48) | PAK4MAPK8TYRO3LRRK2CLK4 | |
| SCHEMBL28354958 | 0.82 | PAK4 (0.49) | PAK4MAPK8TYRO3LRRK2CLK4 | |
| SCHEMBL28355027 | 0.82 | BRD4 (0.49) | PAK4MAPK8TYRO3LRRK2CLK4 | |
| SCHEMBL28355007 | 0.81 | MAPT (0.49) | PAK4MAPK8TYRO3LRRK2CLK4 | |
| SCHEMBL28351501 | 0.79 | POLB (0.50) | LMNAGAAKMT2ANPC1RAB9A | |
| SCHEMBL17623510 | 0.78 | STK17B (0.57) | RHOCRHOAMAPTHTTLMNA | |
| SCHEMBL28351642 | 0.77 | CFTR (0.50) | MAPTMEN1GAAKMT2ASIGMAR1 | |
| SCHEMBL17623511 | 0.76 | TBK1 (0.49) | RHOCRHOAMAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | claimed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | claimed |
| CN-110590807-B | Thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2022-01-07 | — | — | CN | disclosed |
| CN-110590807-A | Novel thieno [3,2-d ] pyrimidine derivative and application thereof | 陕西理工大学 | 2019-12-20 | — | — | CN | disclosed |