Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3161607 | 0.81 | ALDH1A1 (0.53) | KIF11PDE2AALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL5745586 | 0.79 | ALDH1A1 (0.51) | KIF11PDE2AALDH1A1MAPTMEN1 | |
| SCHEMBL9230325 | 0.76 | PDE2A (0.46) | KIF11PDE2AIDO1ALDH1A1MAPT | |
| SCHEMBL31757615 | 0.76 | PDE2A (0.46) | KIF11PDE2AIDO1ALDH1A1MAPT | |
| SCHEMBL11406449 | 0.76 | KIF11 (0.46) | KIF11PDE2AIDO1ALDH1A1MAPT | |
| SCHEMBL3380576 | 0.76 | CA1 (0.47) | KIF11PDE2AIDO1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL28445367 | 0.74 | PDE2A (0.44) | KIF11PDE2AIDO1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL21617978 | 0.74 | IDO1 (0.47) | KIF11PDE2AIDO1ALDH1A1MAPT | |
| Water SCHEMBL5713138 | 0.74 | GAA (0.44) | ALDH1A1MAPTMEN1KMT2AGAA | |
| SCHEMBL11582855 | 0.73 | MAPK1 (0.58) | ALDH1A1MAPTMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104334534-B | Improved process for preparing 1-aryl-5-alkylpyrazole compounds | 勃林格殷格翰动物保健美国公司 | 2020-01-10 | — | — | CN | disclosed |
| EP-3184510-B1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL INC (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-3184510-A1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | Merial, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2852577-B1 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL INC (US) | 2017-03-01 | — | — | EP | disclosed |
| US-9339033-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9273007-B2 | Processes for the preparation of 1-aryl-5-alkyl pyrazole compounds | MERIAL, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2035390-B1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL INC (US) | 2015-12-09 | — | — | EP | disclosed |
| US-20150133506-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | AVENTIS AGRICULTURE (FR) | 2015-05-14 | — | — | US | disclosed |
| EP-2852577-A2 | IMPROVED PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | Merial Limited (US) | 2015-04-01 | — | — | EP | disclosed |
| US-20150073153-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | MERIAL LIMITED (US) | 2015-03-12 | — | — | US | disclosed |
| US-8445519-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | AVENTIS AGRICULTURE (FR) | 2013-05-21 | — | — | US | disclosed |
| EP-2465851-A1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | Aventis Agriculture (FR) | 2012-06-20 | — | — | EP | disclosed |
| US-20100249194-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | MERIAL, INC. | 2010-09-30 | — | — | US | disclosed |
| US-7759381-B2 | 1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | AVENTIS AGRICULTURE (FR) | 2010-07-20 | — | — | US | disclosed |
| EP-2035390-A2 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | Aventis Agriculture (FR) | 2009-03-18 | — | — | EP | disclosed |
| US-20080031902-A1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | MERIAL, INC. | 2008-02-07 | — | — | US | disclosed |
| WO-2008005489-A2 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | AVENTIS AGRICULTURE (FR) | 2008-01-10 | — | — | WO | disclosed |
| US-RE37495-E1 | Substituted 1-arylpyrazoles | BAYER AKTIENGESELLSCHAFT (DE) | 2002-01-01 | — | — | US | disclosed |
| US-5580843-A | INSECTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-03 | — | — | US | disclosed |
| US-4936892-A | HERBICIDES; PLANT GROWTH REGULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1990-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150073153-A1 | PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS | SULT1A1, CYP1B1, CYP2F1 | KIF11 1570/4885PDE2A 4058/4885IDO1 508/4885 |
| US-20100249194-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | CBR3, CBR1, NR5A2 | KIF11 1085/4885PDE2A 2071/4885IDO1 2355/4885 |
| US-20080031902-A1 | 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof | CBR3, CBR1, NR5A2 | KIF11 1111/4885PDE2A 2162/4885IDO1 2339/4885 |
| US-20150133506-A1 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF | CBR3, CBR1, NR5A2 | KIF11 1085/4885PDE2A 2071/4885IDO1 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.