Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19230174 | 0.85 | ALDH1A1 (0.70) | LMNANR3C1ARKMT2AMEN1 | |
| SCHEMBL21292712 | 0.82 | MEN1 (0.67) | LMNAKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL12188930 | 0.79 | SMN1; SMN2 (0.71) | LMNAKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL16197620 | 0.79 | KMT2A (0.75) | LMNAKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL16197384 | 0.78 | LMNA (0.74) | LMNANR3C1ARKMT2AMEN1 | |
| SCHEMBL771186 | 0.78 | MAPT (0.66) | KMT2AMEN1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL28020621 | 0.77 | KMT2A (0.73) | LMNAKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL21309892 | 0.77 | KMT2A (0.60) | LMNAKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL12614743 | 0.77 | KMT2A (0.72) | LMNAKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL12189228 | 0.77 | SMN1; SMN2 (0.73) | LMNAKMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110759889-B | 2-aryl amido substituted thiophene imide ester compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2022-05-20 | — | — | CN | disclosed |
| CN-110759889-A | 2-aryl amido substituted thiophene imide ester compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2020-02-07 | — | — | CN | disclosed |