Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28352384 | 0.76 | MAPK1 (0.37) | USP2SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL16132815 | 0.75 | P2RX7 (0.45) | USP2SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL28355848 | 0.72 | SLC6A2 (0.33) | MAPK1KDM4EALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL25088953 | 0.72 | NR1H2 (0.41) | USP2SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL25095092 | 0.72 | NR1H2 (0.41) | USP2SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL21696862 | 0.71 | NR1H2 (0.40) | USP2SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL15110168 | 0.71 | HTT (0.42) | USP2SMN1; SMN2MAPTMAPK1HTT | |
| SCHEMBL3328949 | 0.70 | HDAC1 (0.44) | MAPTMAPK1HTTNPC1ALDH1A1 | |
| SCHEMBL30149350 | 0.70 | MAPT (0.35) | USP2SMN1; SMN2MAPTMAPK1KDM4E | |
| SCHEMBL9066841 | 0.69 | RECQL (0.49) | USP2SMN1; SMN2MAPTKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110691784-A | Compounds that inhibit MCL-1 protein | 美国安进公司 | 2020-01-14 | — | — | CN | disclosed |