Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.66 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | CPT1A | P50416 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30765198 | 1.00 | LMNA (0.66) | LMNAMAPK1SMN1; SMN2KCNMA1FFAR2 | |
| SCHEMBL29367281 | 0.87 | SMN1; SMN2 (0.67) | LMNAMAPK1SMN1; SMN2KCNMA1ALDH1A1 | |
| SCHEMBL28350045 | 0.87 | SMN1; SMN2 (0.67) | LMNAMAPK1SMN1; SMN2KCNMA1ALDH1A1 | |
| SCHEMBL28350195 | 0.83 | RAB9A (0.67) | LMNAMAPK1SMN1; SMN2POLBRAB9A | |
| SCHEMBL22774165 | 0.78 | ANO1 (0.70) | LMNAANO1MEN1KMT2A | |
| SCHEMBL27374829 | 0.77 | RAB9A (0.61) | LMNAMAPK1SMN1; SMN2KCNMA1FFAR2 | |
| SCHEMBL3869051 | 0.76 | MEN1 (0.55) | LMNASMN1; SMN2ALDH1A1ANO1MEN1 | |
| SCHEMBL21198082 | 0.75 | ANO1 (0.70) | LMNAALDH1A1ANO1MEN1KMT2A | |
| SCHEMBL23175242 | 0.75 | GLA (0.72) | LMNASMN1; SMN2KCNMA1FFAR2ALDH1A1 | |
| SCHEMBL21198085 | 0.75 | ANO1 (0.76) | ANO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110753691-A | Compound (I) | 豪夫迈·罗氏有限公司 | 2020-02-04 | — | — | CN | disclosed |