Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28350045 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAMAPK1RAB9ANPC1 | |
| SCHEMBL28353263 | 0.87 | LMNA (0.66) | SMN1; SMN2LMNAMAPK1RAB9ANPC1 | |
| SCHEMBL30765198 | 0.87 | LMNA (0.66) | SMN1; SMN2LMNAMAPK1RAB9ANPC1 | |
| SCHEMBL28350195 | 0.86 | RAB9A (0.67) | SMN1; SMN2LMNAMAPK1RAB9ANPC1 | |
| SCHEMBL20577404 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAMAPK1RAB9ANPC1 | |
| SCHEMBL28354689 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2LMNAMAPK1RAB9ANPC1 | |
| SCHEMBL30765132 | 0.78 | LMNA (0.63) | SMN1; SMN2LMNAMAPK1RAB9ANPC1 | |
| SCHEMBL1340856 | 0.77 | RAB9A (0.58) | SMN1; SMN2LMNAMAPK1RAB9ANPC1 | |
| SCHEMBL29855806 | 0.77 | NPC1 (0.62) | SMN1; SMN2RAB9ANPC1ALDH1A1POLB | |
| SCHEMBL28350334 | 0.77 | NPC1 (0.62) | SMN1; SMN2RAB9ANPC1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110753691-B | Compounds for therapeutic and/or prophylactic treatment of cancer | 豪夫迈·罗氏有限公司 | 2024-02-02 | — | — | CN | disclosed |
| EP-3986565-B1 | NEW EGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2023-08-30 | — | — | EP | disclosed |
| EP-3630754-B1 | ISOINDOLINE-ACETYLENE COMPOUNDS FOR THE TREATMENT OF CANCER | HOFFMANN LA ROCHE (CH) | 2022-07-27 | — | — | EP | disclosed |
| CN-113993589-A | Novel EGFR inhibitors | 豪夫迈·罗氏有限公司 | 2022-01-28 | — | — | CN | disclosed |