Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIB | P23284 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7118017 | 0.82 | PPIB (0.43) | PPIBALDH1A1KDM4ECYP19A1SMN1; SMN2 | |
| SCHEMBL927371 | 0.81 | SIGMAR1 (0.45) | ALDH1A1KDM4ECYP19A1SMN1; SMN2MAPT | |
| SCHEMBL27288753 | 0.81 | SIGMAR1 (0.45) | ALDH1A1KDM4ECYP19A1SMN1; SMN2MAPT | |
| SCHEMBL11013389 | 0.70 | MEN1 (0.43) | ALDH1A1KDM1ASIGMAR1MEN1KMT2A | |
| SCHEMBL30872986 | 0.70 | RIPK1 (0.53) | PPIBALDH1A1KDM4ECYP19A1SMN1; SMN2 | |
| SCHEMBL7154660 | 0.70 | MAOB (0.47) | PPIBALDH1A1KDM4ECYP19A1SMN1; SMN2 | |
| SCHEMBL29757571 | 0.69 | MAOB (0.39) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL6191270 | 0.69 | ALDH1A1 (0.43) | PPIBALDH1A1KDM4ECYP19A1SMN1; SMN2 | |
| SCHEMBL2120395 | 0.69 | ATM (0.44) | PPIBKDM4ECYP19A1SMN1; SMN2MAPT | |
| SCHEMBL29375243 | 0.68 | KDM4E (0.60) | PPIBALDH1A1KDM4ECYP19A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113329792-B | Substituted 3- (1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof | 诺华股份有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-112585136-B | Urea compounds and compositions as SMARCA2/BRM atpase inhibitors | 诺华股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-117794929-A | Selective BCL-XL PROTAC compounds and methods of use | 法国施维雅药厂 | 2024-03-29 | — | — | CN | disclosed |
| CN-117500803-A | Amino-substituted heterocycles for the treatment of cancers with EGFR mutations | 纽威伦特公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-117355333-A | Combination comprising anti-TM 4SF1 antibody and immunotherapeutic agent and method of use thereof | 安吉克公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-117355304-A | ALK-5 inhibitors and uses thereof | 住友制药肿瘤公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-117122707-A | combination therapy | 意大利国际先进加速器应用有限公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-117098776-A | Use of anti-TGF-beta antibodies and other therapeutic agents for the treatment of proliferative diseases | 诺华股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-116829143-A | Forms and formulations of non-receptor tyrosine kinase 1 (TNK 1) inhibitors | 住友制药肿瘤公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-116761635-A | BCL-XL inhibitor antibody drug conjugates and methods of use thereof | 诺华股份有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-112867512-A | Combination therapy | 意大利国际先进加速器应用有限公司 | 2021-05-28 | — | — | CN | disclosed |
| CN-112585136-A | Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors | 诺华股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-112584875-A | Stabilized, concentrated solutions of radionuclide complexes | 先进加速器应用公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-112334194-A | 3- (5-amino-1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives and their use in the treatment of IKAROS family Zinc finger 2(IKZF2) dependent diseases | 诺华股份有限公司 | 2021-02-05 | — | — | CN | disclosed |
| CN-112261970-A | 3- (5-hydroxy-1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives and their use in the treatment of IKAROS family Zinc finger 2(IKZF2) dependent diseases | 诺华股份有限公司 | 2021-01-22 | — | — | CN | disclosed |
| CN-111107868-A | Antibody cytokine transplantation proteins and methods of use | 诺华股份有限公司 | 2020-05-05 | — | — | CN | disclosed |
| CN-111032085-A | Combination of an immune checkpoint antagonist and a RANK-L (NF-KB ligand) antagonist or bispecific binding molecules thereof for use in cancer treatment or prevention and uses thereof | 昆士兰医学研究所理事会 | 2020-04-17 | — | — | CN | disclosed |
| CN-110799218-A | Antibody conjugates comprising STING agonists | 诺华股份有限公司 | 2020-02-14 | — | — | CN | disclosed |
| CN-110678183-A | Antibody conjugates comprising TOLL-like receptor agonists and combination therapies | 诺华股份有限公司 | 2020-01-10 | — | — | CN | disclosed |
| CN-110662762-A | Antibody cytokine transplantation proteins and methods for treating cancer | 诺华股份有限公司 | 2020-01-07 | — | — | CN | disclosed |