Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28356556 | 0.94 | HPGD (0.47) | HPGDALDH1A1SMN1; SMN2KDM4ECACNA2D1 | |
| SCHEMBL28352367 | 0.90 | GLA (0.43) | HPGDSMN1; SMN2KDM4ECACNA2D1 | |
| SCHEMBL28356143 | 0.90 | CACNA2D1 (0.41) | HPGDALDH1A1SMN1; SMN2CACNA2D1PLK1 | |
| SCHEMBL28356151 | 0.88 | HPGD (0.40) | HPGDALDH1A1SMN1; SMN2PPARGNCOA2 | |
| SCHEMBL28352526 | 0.87 | PLK1 (0.39) | HPGDALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL28352337 | 0.86 | HPGD (0.43) | HPGDALDH1A1SMN1; SMN2KDM4EPPARG | |
| SCHEMBL28355861 | 0.85 | TSHR (0.40) | HPGDSMN1; SMN2CACNA2D1MAPK1HTT | |
| SCHEMBL28356404 | 0.82 | DCTPP1 (0.41) | HPGDALDH1A1SMN1; SMN2CACNA2D1KMT2A | |
| SCHEMBL28356002 | 0.82 | GABRA2 (0.44) | HPGDALDH1A1SMN1; SMN2KDM4ECACNA2D1 | |
| SCHEMBL28352608 | 0.81 | HPGD (0.43) | HPGDALDH1A1SMN1; SMN2CACNA2D1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107162982-B | Imidazole compounds with anticancer activity and derivatives thereof | 广东药科大学 | 2020-02-11 | — | — | CN | disclosed |