SCHEMBL28356752

SCHEMBL28356752

COc1cc(Oc2ccc(F)cc2)cc(OC)c1C=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.48
ERN1 O75460 2/20 0.47
ALDH1A1 P00352 3/20 0.46
L3MBTL1 Q9Y468 2/20 0.43
LMNA P02545 2/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
SOS1 Q07889 1/20 0.42
NFE2L2 Q16236 3/20 0.42
TRPA1 O75762 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
FDFT1 P37268 1/20 0.40
MAPK1 P28482 1/20 0.40
HTT P42858 1/20 0.40
GAPDH P04406 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28360510 0.90 ERN1 (0.65) MAOAERN1ALDH1A1L3MBTL1SOS1
SCHEMBL3818395 0.86 ERN1 (0.60) ERN1ALDH1A1LMNACYP1A2
SCHEMBL28360529 0.82 ALDH1A1 (0.67) ERN1ALDH1A1L3MBTL1LMNACYP1A2
SCHEMBL9049946 0.79 NFE2L2 (0.55) ERN1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL6233232 0.78 MAOB (0.54) MAOAERN1ALDH1A1L3MBTL1LMNA
SCHEMBL746009 0.78 ERN1 (0.50) MAOAERN1ALDH1A1L3MBTL1LMNA
2,4,6-Trimethoxybenzaldehyde SCHEMBL34873 0.76 ERN1 (0.74) MAOAERN1ALDH1A1LMNACYP1A2
SCHEMBL26936442 0.75 TTR (0.49) ALDH1A1L3MBTL1LMNACYP1A2CYP2C9
SCHEMBL9047353 0.74 ALDH1A1 (0.64) ALDH1A1L3MBTL1LMNANFE2L2SMN1; SMN2
SCHEMBL2028440 0.74 TTR (0.51) ERN1ALDH1A1L3MBTL1LMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110845345-B Aromatic diamine monomer and preparation method thereof 中国科学院长春应用化学研究所 2021-11-09 CN disclosed
CN-110791833-B Polyimide fiber and preparation method thereof 中国科学院长春应用化学研究所 2021-02-05 CN disclosed
CN-110845345-A Aromatic diamine monomer and preparation method thereof 中国科学院长春应用化学研究所 2020-02-28 CN disclosed
CN-110791833-A Polyimide fiber and preparation method thereof 中国科学院长春应用化学研究所 2020-02-14 CN disclosed