Tyrosine

SCHEMBL28356785

CC(C)[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	GLP1R	P43220	11/20	0.40

▸	SCTR	P47872	1/20	0.40

▸	GCGR	P47871	1/20	0.39

▸	C5AR1	P21730	1/20	0.38

▸	IL23R	Q5VWK5	1/20	0.38

▸	VIPR2	P41587	2/20	0.37

▸	VIPR1	P32241	1/20	0.37

▸	TUBB4A	P04350	1/20	0.37

▸	TUBB	P07437	1/20	0.37

▸	TUBA3C	P0DPH7	1/20	0.37

▸	TUBA1B	P68363	1/20	0.37

▸	TUBA4A	P68366	1/20	0.37

▸	TUBB4B	P68371	1/20	0.37

▸	TUBB3	Q13509	1/20	0.37

▸	TUBB2A	Q13885	1/20	0.37

▸	TUBB8	Q3ZCM7	1/20	0.37

▸	TUBA3E	Q6PEY2	1/20	0.37

▸	TUBA1A	Q71U36	1/20	0.37

▸	TUBA1C	Q9BQE3	1/20	0.37

▸	TUBB6	Q9BUF5	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Arginine SCHEMBL16762310	0.86	GSR (0.34)	GLP1RSCTRGCGRC5AR1TUBB4A
Tyrosine SCHEMBL29038277	0.86	TUBB4A (0.40)	GLP1RSCTRGCGRC5AR1TUBB4A
Tyrosine SCHEMBL29278795	0.86	TUBB4A (0.40)	GLP1RSCTRGCGRC5AR1TUBB4A
Tyrosine SCHEMBL28368653	0.84	TUBB4A (0.40)	GLP1RSCTRGCGRC5AR1VIPR2
Tyrosine SCHEMBL29194960	0.84	GLP1R (0.38)	GLP1RSCTRGCGRVIPR2VIPR1
Tyrosine SCHEMBL28420652	0.84	NPY4R (0.40)	NPY4R
Tyrosine SCHEMBL16762299	0.84	NPY4R (0.48)	NPY4R
Tyrosine SCHEMBL27465555	0.84	TUBB4A (0.39)	GLP1RSCTRGCGRC5AR1TUBB4A
Arginine SCHEMBL28861117	0.84	ANPEP (0.37)	GLP1RSCTRC5AR1TUBB4ATUBB
Arginine SCHEMBL28894087	0.83	APLNR (0.36)	GLP1RSCTRGCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-106831948-B	Neuropeptide and synthesis method and application thereof	东南大学	2020-02-18	—	—	CN	disclosed