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Arginine

Arginine

SCHEMBL28894087

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ APLNR P35414 2/20 0.36
▸ GLP1R P43220 12/20 0.35
▸ SCTR P47872 1/20 0.35
▸ GCGR P47871 4/20 0.35
▸ PTH1R Q03431 2/20 0.34
▸ CALCR P30988 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Arginine SCHEMBL28894222 1.00 APLNR (0.36) APLNRGLP1RSCTRGCGRPTH1R
Arginine SCHEMBL27551617 0.93 APLNR (0.38) APLNRGLP1RSCTRGCGRPTH1R
Arginine SCHEMBL27495388 0.91 PTH1R (0.38) APLNRGLP1RPTH1R
Arginine SCHEMBL27611401 0.87 PTH1R (0.36) APLNRGLP1RPTH1RCALCR
Arginine SCHEMBL27607779 0.87 APLNR (0.36) APLNR
Tyrosine SCHEMBL27636887 0.83 GLP1R (0.40) GLP1RSCTRGCGR
Tyrosine SCHEMBL28356785 0.83 GLP1R (0.40) GLP1RSCTRGCGR
Cystine SCHEMBL27644422 0.83 GLP1R (0.41) GLP1RSCTRGCGR
Arginine SCHEMBL6481630 0.83 GLP1R (0.35) GLP1R
Arginine SCHEMBL27730473 0.82 GLP1R (0.34) GLP1RSCTRGCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115043926-A Polypeptide fragment targeting GSDMD and application thereof in preparation of medicines for preventing and treating cell apoptosis and sepsis 中国科学技术大学 2022-09-13 — — CN disclosed