Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 7/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL690033 | 1.00 | THRB (0.48) | THRBTSHRHCAR2POLBAPEX1 | |
| Maleic Acid SCHEMBL690032 | 1.00 | THRB (0.48) | THRBTSHRHCAR2POLBAPEX1 | |
| SCHEMBL29132467 | 0.93 | HCAR2 (0.53) | THRBTSHRHCAR2POLBAPEX1 | |
| Maleic Acid SCHEMBL27995521 | 0.93 | THRB (0.43) | THRBTSHRHCAR2POLBAPEX1 | |
| Maleic Acid SCHEMBL690359 | 0.89 | TSHR (0.53) | THRBTSHRHCAR2POLBAPEX1 | |
| Fumaric Acid SCHEMBL690360 | 0.89 | TSHR (0.53) | THRBTSHRHCAR2POLBAPEX1 | |
| Acrylic Acid SCHEMBL3447729 | 0.89 | TSHR (0.50) | THRBTSHRPOLBAPEX1HTT | |
| Acrylic Acid SCHEMBL27980474 | 0.89 | TSHR (0.50) | THRBTSHRPOLBAPEX1HTT | |
| Acetic Acid SCHEMBL2590428 | 0.88 | THRB (0.55) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL29229747 | 0.88 | THRB (0.59) | THRBTSHRPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110801535-A | Eyelid bionic bracket with double-layer composite structure and construction method thereof | 浙江大学 | 2020-02-18 | — | — | CN | disclosed |