Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 7/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL28356830 | 1.00 | THRB (0.48) | THRBTSHRHCAR2POLBAPEX1 | |
| Maleic Acid SCHEMBL690032 | 1.00 | THRB (0.48) | THRBTSHRHCAR2POLBAPEX1 | |
| SCHEMBL29132467 | 0.93 | HCAR2 (0.53) | THRBTSHRHCAR2POLBAPEX1 | |
| Maleic Acid SCHEMBL27995521 | 0.93 | THRB (0.43) | THRBTSHRHCAR2POLBAPEX1 | |
| Maleic Acid SCHEMBL690359 | 0.89 | TSHR (0.53) | THRBTSHRHCAR2POLBAPEX1 | |
| Fumaric Acid SCHEMBL690360 | 0.89 | TSHR (0.53) | THRBTSHRHCAR2POLBAPEX1 | |
| Acrylic Acid SCHEMBL3447729 | 0.89 | TSHR (0.50) | THRBTSHRPOLBAPEX1HTT | |
| Acrylic Acid SCHEMBL27980474 | 0.89 | TSHR (0.50) | THRBTSHRPOLBAPEX1HTT | |
| Acetic Acid SCHEMBL2590428 | 0.88 | THRB (0.55) | THRBTSHRPOLBAPEX1HTT | |
| SCHEMBL29229747 | 0.88 | THRB (0.59) | THRBTSHRPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215194-A1 | ENHANCED REMOVABILITY OF NAIL COATINGS USING ACIDIC COPOLYMERS FOR TRIGGERED REMOVAL WITH AQUEOUS BASED REMOVER | ARKEMA FRANCE (FR) | 2025-10-16 | — | — | WO | claimed |
| WO-2025215194-A1 | ENHANCED REMOVABILITY OF NAIL COATINGS USING ACIDIC COPOLYMERS FOR TRIGGERED REMOVAL WITH AQUEOUS BASED REMOVER | ARKEMA FRANCE (FR) | 2025-10-16 | — | — | WO | disclosed |
| CN-110520794-B | Polymerizable composition, photosensitive composition for black matrix, and photosensitive composition for black column spacer | 株式会社艾迪科 | 2025-04-04 | — | — | CN | disclosed |
| CN-110546134-B | Oxime ester compound and photopolymerization initiator containing the same | 株式会社艾迪科 | 2024-12-20 | — | — | CN | disclosed |
| CN-110520796-B | Polymerizable composition, photosensitive composition for black matrix, and photosensitive composition for black column spacer | 株式会社艾迪科 | 2024-11-12 | — | — | CN | disclosed |
| WO-2024202696-A1 | COMPOSITION, BLACK MATRIX, CURED PRODUCT, METHOD FOR PRODUCING CURED PRODUCT, AND DISPLAY DEVICE | 株式会社ADEKA | 2024-10-03 | — | — | WO | disclosed |
| CN-109476773-B | Curable composition, cured product, and method for producing cured product | 株式会社艾迪科 | 2022-05-13 | — | — | CN | disclosed |
| EP-3436537-B1 | ANAEROBICALLY CURABLE (METH)ACRYLATE COMPOSITIONS | Henkel IP & Holding GmbH (DE) | 2021-09-29 | — | — | EP | disclosed |
| US-11111416-B2 | Anaerobically curable (meth)acrylate compositions | Henkel IP & Holding GmbH (DE) | 2021-09-07 | — | — | US | disclosed |
| CN-109196066-B | Anaerobically curable (meth) acrylate compositions | 汉高知识产权控股有限责任公司 | 2021-08-24 | — | — | CN | disclosed |
| US-20100129753-A1 | ALKALI-DEVELOPABLE PHOTOSENSITIVE RESIN COMPOSITION AND BETA-DIKETONE COMPOUND | ADEKA CORPORATION (JP) | 2010-05-27 | — | — | US | disclosed |
| EP-2175320-A1 | ALKALI-DEVELOPABLE PHOTOSENSITIVE RESIN COMPOSITION AND -DIKETONE COMPOUND | Adeka Corporation (JP) | 2010-04-14 | — | — | EP | disclosed |
| US-7695895-B2 | photopolymerizable unsaturated binder obtained by adding unsaturated monobasic acid polyfunctional epoxy resin to form epoxy adduct and allowing epoxy adduct and polybasic acid anhydride to react; color filters, liquid crystal displays, image sensors | TOPPAN PRINTING CO., LTD. (JP) | 2010-04-13 | — | — | US | disclosed |
| US-20090202750-A1 | COLORED ALKALI-DEVELOPABLE PHOTOSENSITIVE RESIN COMPOSITION AND COLOR FILTER USING THE SAME | TOPPAN PRINTING CO., LTD. (JP) | 2009-08-13 | — | — | US | disclosed |
| EP-0872529-B2 | BINDER FOR BUILDING STRUCTURES | ASAHI CHEMICAL IND (JP) | 2008-07-09 | — | — | EP | disclosed |
| EP-1906243-A1 | ALKALINE-DEVELOPABLE PHOTOSENSITIVE COLORED COMPOSITION | Toppan Printing Co., Ltd. (JP) | 2008-04-02 | — | — | EP | disclosed |
| US-20070292805-A1 | photopolymerizable unsaturated binder obtained by adding unsaturated monobasic acid polyfunctional epoxy resin to form epoxy adduct and allowing epoxy adduct and polybasic acid anhydride to react; color filters, liquid crystal displays, image sensors | ADEKA CORPORATION (JP) | 2007-12-20 | — | — | US | disclosed |
| EP-0872529-B1 | BINDER FOR BUILDING STRUCTURES | ASAHI CHEMICAL IND (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6015845-A | Binder for building structure | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2000-01-18 | — | — | US | disclosed |
| EP-0872529-A1 | BINDER FOR BUILDING STRUCTURES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1998-10-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100129753-A1 | ALKALI-DEVELOPABLE PHOTOSENSITIVE RESIN COMPOSITION AND BETA-DIKETONE COMPOUND | RPS14, ACAD11, OR10J3 | THRB 969/4885TSHR 3404/4885HCAR2 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.