Thiohydantoin

Thiohydantoin

SCHEMBL28357993

N=[N+]=N.O=C1CNC(=S)N1

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 1/20 0.31
GSK3B P49841 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thiohydantoin SCHEMBL31955553 0.90
Thiohydantoin SCHEMBL3520254 0.90
Thiohydantoin SCHEMBL27396584 0.85 MAPT (0.33) GSK3AGSK3B
Hydantoin SCHEMBL5656545 0.83 CRBN (0.41) GSK3AGSK3B
Thiohydantoin SCHEMBL1976347 0.81
Biphenyl SCHEMBL27404603 0.76 SIRT2 (0.42) GSK3AGSK3B
Thiohydantoin SCHEMBL27996535 0.74 FFAR3 (0.39)
Thiohydantoin SCHEMBL5450565 0.72 ALDH1A1 (0.46)
Thiohydantoin SCHEMBL8760331 0.72 TP53 (0.31)
Thiohydantoin SCHEMBL28554784 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110746400-B Androgen receptor targeted fluorescent probe and preparation method thereof 郑州大学 2021-12-17 CN disclosed
CN-110746400-A Androgen receptor targeted fluorescent probe and preparation method thereof 郑州大学 2020-02-04 CN disclosed