Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydantoin SCHEMBL28543076 | 0.81 | ALDH1A1 (0.50) | ALDH1A1FKBP5 | |
| Thiohydantoin SCHEMBL3520254 | 0.76 | — | — | |
| Thiohydantoin SCHEMBL31955553 | 0.76 | — | — | |
| Succinimide SCHEMBL27751504 | 0.75 | ALDH1A1 (0.56) | ALDH1A1FKBP5 | |
| Imidazole SCHEMBL28243896 | 0.71 | — | — | |
| Hydantoin SCHEMBL5656545 | 0.70 | CRBN (0.41) | — | |
| Imidazole SCHEMBL11824031 | 0.69 | — | — | |
| Thiohydantoin SCHEMBL1976347 | 0.69 | — | — | |
| Imidazole SCHEMBL2635292 | 0.68 | — | — | |
| Imidazole SCHEMBL897 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203344-A1 | SYNTHESIS OF IMIDAZOLE 2-THIONES VIA THIOHYDANTOINS | ALLERGAN, INC. | 2007-08-30 | — | — | US | claimed |
| WO-2007041048-A2 | SYNTHESIS OF IMIDAZOLE-2-THIONES VIA THIOHYDANTOINS | ALLERGAN, INC. (US) | 2007-04-12 | — | — | WO | claimed |
| US-20070196360-A1 | SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS | TOPOTARGET A/S | 2007-08-23 | — | — | US | disclosed |
| EP-1373494-B1 | SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS | TOPOTARGET AS (DK) | 2006-03-01 | — | — | EP | disclosed |
| EP-1373494-A2 | SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS | Topo Target A/S (DK) | 2004-01-02 | — | — | EP | disclosed |
| US-20030032625-A1 | Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors | TOPO TARGET APS (DK) | 2003-02-13 | — | — | US | disclosed |
| WO-2002078679-A2 | SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS | TOPO TARGET APS (DK) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030032625-A1 | Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors | TOP2A, TOP2B, TOP1 | ALDH1A1 2038/4885FKBP5 1723/4885 |
| US-20070203344-A1 | SYNTHESIS OF IMIDAZOLE 2-THIONES VIA THIOHYDANTOINS | TPMT, NISCH, IMPDH2 | ALDH1A1 784/4885FKBP5 193/4885 |
| US-20070196360-A1 | SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS | TOP2A, TOP2B, TOP1 | ALDH1A1 2038/4885FKBP5 1723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.