Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.57 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28361850 | 1.00 | MEN1 (0.74) | MEN1KMT2AKDM4ENPSR1MAPT | |
| SCHEMBL28358398 | 1.00 | MEN1 (0.74) | MEN1KMT2AKDM4ENPSR1MAPT | |
| SCHEMBL30511846 | 0.91 | KDM4E (0.69) | MEN1KMT2AKDM4ENPSR1MAPT | |
| SCHEMBL30553921 | 0.90 | MEN1 (0.61) | MEN1KMT2AKDM4ENPSR1MAPT | |
| SCHEMBL3456311 | 0.86 | MEN1 (1.00) | MEN1KMT2AKDM4ENPSR1MAPT | |
| SCHEMBL3456310 | 0.86 | MEN1 (1.00) | MEN1KMT2AKDM4ENPSR1MAPT | |
| SCHEMBL28358149 | 0.85 | MAPT (0.58) | MEN1KMT2AKDM4ENPSR1MAPT | |
| SCHEMBL30173938 | 0.84 | MEN1 (0.73) | MEN1KMT2AKDM4ENPSR1MAPT | |
| SCHEMBL28560880 | 0.84 | MEN1 (0.73) | MEN1KMT2AKDM4ENPSR1MAPT | |
| SCHEMBL30511879 | 0.84 | MEN1 (0.73) | MEN1KMT2AKDM4ENPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110746355-A | Phenylpyrazole compound, pharmaceutical composition, preparation method and application thereof | 中国科学院上海有机化学研究所 | 2020-02-04 | — | — | CN | claimed |
| CN-110746355-B | Phenylpyrazole compound, pharmaceutical composition, and preparation method and application thereof | 中国科学院上海有机化学研究所 | 2023-08-11 | — | — | CN | disclosed |
| CN-110746355-A | Phenylpyrazole compound, pharmaceutical composition, preparation method and application thereof | 中国科学院上海有机化学研究所 | 2020-02-04 | — | — | CN | disclosed |