Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 13/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2843300 | 0.88 | CASR (0.52) | CASRNR1I2GRM5 | |
| SCHEMBL2837296 | 0.87 | CASR (0.49) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2840722 | 0.87 | CASR (0.73) | CASRNR1I2 | |
| Hydrochloric Acid SCHEMBL2835851 | 0.87 | CASR (0.72) | CASRNR1I2 | |
| SCHEMBL2838847 | 0.84 | CASR (0.55) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3345007 | 0.83 | CASR (0.80) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL13418278 | 0.80 | CASR (0.86) | CASRNR1I2 | |
| SCHEMBL4147810 | 0.80 | CASR (0.56) | CASRNR1I2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3344554 | 0.79 | CASR (1.00) | CASRNR1I2 | |
| Hydrochloric Acid SCHEMBL3345010 | 0.79 | CASR (0.98) | CASRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039913-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |