Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 5/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2835830 | 0.88 | CASR (0.66) | CASRNR1I2GRM5 | |
| SCHEMBL2835466 | 0.86 | CASR (0.54) | CASRNR1I2CTSLCTSSCTSK | |
| SCHEMBL2840670 | 0.80 | HTR2C (0.40) | HTR2CSLC6A4PSEN1PSEN2APH1B | |
| SCHEMBL2837495 | 0.77 | HTR2C (0.41) | CASRHTR2CSLC6A4PSEN1PSEN2 | |
| SCHEMBL2837296 | 0.76 | CASR (0.49) | CASRNR1I2 | |
| SCHEMBL2840722 | 0.76 | CASR (0.73) | CASRNR1I2 | |
| Hydrochloric Acid SCHEMBL2835851 | 0.75 | CASR (0.72) | CASRNR1I2 | |
| SCHEMBL2838847 | 0.73 | CASR (0.55) | CASRNR1I2 | |
| SCHEMBL3345007 | 0.72 | CASR (0.80) | CASRNR1I2 | |
| SCHEMBL13418278 | 0.69 | CASR (0.86) | CASRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039913-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |