Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | LAP3 | P28838 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11705596 | 0.83 | CYP2D6 (0.38) | LMNACYP2D6CYP1A2ALDH1A1ATM | |
| SCHEMBL11663267 | 0.79 | LMNA (0.45) | LMNACYP2D6ALDH1A1ALOX15ANPEP | |
| SCHEMBL28799638 | 0.78 | LMNA (0.41) | LMNACYP2D6CYP1A2ALDH1A1ANPEP | |
| SCHEMBL27864512 | 0.78 | LMNA (0.41) | LMNACYP2D6CYP1A2ALDH1A1ANPEP | |
| SCHEMBL8187179 | 0.78 | LMNA (0.44) | LMNACYP2D6ALDH1A1ALOX15ANPEP | |
| SCHEMBL19544862 | 0.75 | L3MBTL1 (0.51) | LMNACYP2D6CYP1A2ALDH1A1ATM | |
| SCHEMBL14875141 | 0.75 | LMNA (0.45) | LMNACYP2D6CYP1A2ALDH1A1ALOX15 | |
| SCHEMBL11708044 | 0.74 | MAOA (0.35) | LMNAALDH1A1AOC3MAOAPTGS1 | |
| SCHEMBL1369857 | 0.74 | SLC6A2 (0.43) | CYP2D6CYP1A2ALDH1A1ALOX15ATM | |
| SCHEMBL11713703 | 0.73 | CA4 (0.43) | ALDH1A1ALOX15ATML3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110831584-B | Targeted drug rescue with novel compositions, combinations and methods thereof | 埃克塞瓦有限责任公司 | 2023-03-10 | — | — | CN | disclosed |
| CN-110831584-A | Targeted drug rescue with novel compositions, combinations and methods thereof | 埃克塞瓦有限责任公司 | 2020-02-21 | — | — | CN | disclosed |