Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922724 | 1.00 | SYK (0.46) | SYKMAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL29552431 | 0.87 | SYK (0.48) | SYKMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL15091096 | 0.85 | SYK (0.56) | SYKMAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL29922622 | 0.83 | SYK (0.43) | SYKMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL29552428 | 0.83 | SYK (0.43) | SYKMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28359397 | 0.83 | SYK (0.43) | SYKMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL29922716 | 0.83 | KDM4E (0.41) | SYKMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL28359360 | 0.83 | KDM4E (0.41) | SYKMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL28359009 | 0.82 | SYK (0.46) | SYKMAPTALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL29922768 | 0.82 | SYK (0.46) | SYKALDH1A1KDM4ECCNB2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |