Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359360 | 1.00 | KDM4E (0.41) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL29551893 | 0.88 | MEN1 (0.40) | KDM4ENPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL29922724 | 0.83 | SYK (0.46) | KDM4EKMT2AALDH1A1L3MBTL1MEN1 | |
| SCHEMBL28359017 | 0.83 | SYK (0.46) | KDM4EKMT2AALDH1A1L3MBTL1MEN1 | |
| SCHEMBL15091106 | 0.81 | LMNA (0.41) | KDM4EALDH1A1HTTLMNASYK | |
| SCHEMBL29922914 | 0.80 | TYK2 (0.50) | L3MBTL1MAPTJAK2JAK1TYK2 | |
| SCHEMBL28359104 | 0.80 | TYK2 (0.50) | L3MBTL1MAPTJAK2JAK1TYK2 | |
| SCHEMBL28359397 | 0.77 | SYK (0.43) | KDM4ERAB9AKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL29552428 | 0.77 | SYK (0.43) | KDM4ERAB9AKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL29922622 | 0.77 | SYK (0.43) | KDM4ERAB9AKMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |