Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9982800 | 0.98 | ALDH1A1 (0.49) | ALDH1A1ELANEKMT2AUSP2ALOX15 | |
| SCHEMBL2227741 | 0.86 | ALDH1A1 (0.47) | ALDH1A1ELANEKMT2AUSP2ALOX15 | |
| SCHEMBL11047321 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1GAAESR1 | |
| SCHEMBL361916 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KMT2ANPSR1MAPTMEN1 | |
| SCHEMBL5724458 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1GAASMN1; SMN2 | |
| SCHEMBL7586365 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KMT2ANPSR1MAPTMEN1 | |
| SCHEMBL27854250 | 0.80 | HSD11B1 (0.47) | ALDH1A1ELANETSHRMAPTSMN1; SMN2 | |
| SCHEMBL28887671 | 0.79 | ALDH1A1 (0.45) | ALDH1A1KMT2AUSP2ALOX15TSHR | |
| SCHEMBL10637725 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1GAAESR1 | |
| SCHEMBL443434 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPTMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318214-B2 | Method for treating onychoschizia | POLICHEM S.A. (LU) | 2012-11-27 | — | — | US | disclosed |
| US-20100215780-A1 | Method for treating onychoschizia | POLICHEM SA (LU) | 2010-08-26 | — | — | US | disclosed |
| EP-1635852-B1 | USE OF NAIL RESTRUCTURING COMPOSITIONS FOR TOPICAL APPLICATION IN ONYCHOSCHIZIA | POLICHEM SA (LU) | 2007-08-15 | — | — | EP | disclosed |
| US-20060134039-A1 | Nail restructuring compositions for topical application | POLICHEM SA (LU) | 2006-06-22 | — | — | US | disclosed |
| EP-1635852-A1 | NAIL RESTRUCTURING COMPOSITIONS FOR TOPICAL APPLICATION | Polichem S.A. (LU) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004112814-A1 | NAIL RESTRUCTURING COMPOSITIONS FOR TOPICAL APPLICATION | POLICHEM S.A. (LU) | 2004-12-29 | — | — | WO | disclosed |
| EP-0510561-B1 | Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | POLI IND CHIMICA SPA (IT) | 1996-07-24 | — | — | EP | disclosed |
| US-5369131-A | Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | POLI INDUSTRIA CHIMICA S.P.A. (IT) | 1994-11-29 | — | — | US | disclosed |
| EP-0510561-A1 | Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1992-10-28 | — | — | EP | disclosed |