Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.70 |
| ▸ | RAB9A | P51151 | 8/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MLYCD | O95822 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879030 | 0.88 | RAB9A (0.88) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL10943445 | 0.88 | RAB9A (0.88) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL5472654 | 0.87 | RAF1 (0.59) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL1365179 | 0.87 | CA12 (0.61) | SMN1; SMN2GAAALDH1A1KDM4EKMT2A | |
| SCHEMBL28306812 | 0.87 | CA12 (0.61) | SMN1; SMN2GAAALDH1A1KDM4EKMT2A | |
| SCHEMBL29649031 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ANPC1GAAALDH1A1 | |
| SCHEMBL2833360 | 0.85 | NPC1 (0.65) | SMN1; SMN2RAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL31311144 | 0.85 | NPC1 (0.65) | SMN1; SMN2RAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL9337665 | 0.83 | MLYCD (0.76) | RAB9ANPC1KDM4EMEN1KMT2A | |
| SCHEMBL6263516 | 0.83 | MLYCD (0.76) | RAB9ANPC1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2010-07-01 | — | — | US | disclosed |
| US-7696231-B2 | Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs) | LABORATOIRES SERONO SA (CH) | 2010-04-13 | — | — | US | disclosed |
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. | 2005-02-24 | — | — | US | disclosed |
| EP-1439834-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003037328-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-05-08 | — | — | WO | disclosed |
| EP-0346713-B1 | BENZAMIDINES USEFUL AS ULTRAVIOLET LIGHT ABSORBERS | L. GIVAUDAN & CIE Société Anonyme (CH) | 1992-09-16 | — | — | EP | disclosed |
| US-5011628-A | N,N'-diarylbenzamidines useful as ultraviolet light absorbers | GIVAUDAN CORPORATION (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0346713-A1 | Benzamidines useful as ultraviolet light absorbers | L. GIVAUDAN & CIE Société Anonyme (CH) | 1989-12-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | PTPRO, PTPRE, PTPRZ1 | SMN1; SMN2 4885/4885RAB9A 3219/4885NPC1 1600/4885 |
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | PTPRO, PTPRE, PTPRZ1 | SMN1; SMN2 4885/4885RAB9A 3161/4885NPC1 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.