SCHEMBL29649031

SCHEMBL29649031

CCOC(=O)c1ccc(C#N)cc1.N#Cc1ccc(C(=O)NN)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.56
KDM4E B2RXH2 2/20 0.56
ALDH1A1 P00352 2/20 0.56
MAPT P10636 2/20 0.54
LMNA P02545 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
MAOA P21397 1/20 0.53
KMT2A Q03164 4/20 0.52
GAA P10253 3/20 0.52
MEN1 O00255 2/20 0.52
ADRB2 P07550 1/20 0.51
ADRB1 P08588 1/20 0.51
ADRB3 P13945 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28306812 0.89 CA12 (0.61) SMN1; SMN2KDM4EALDH1A1MAPTLMNA
SCHEMBL1365179 0.89 CA12 (0.61) SMN1; SMN2KDM4EALDH1A1MAPTLMNA
SCHEMBL11839699 0.87 MAPT (0.69) SMN1; SMN2KDM4EALDH1A1MAPTLMNA
SCHEMBL2836025 0.86 SMN1; SMN2 (0.70) SMN1; SMN2KDM4EALDH1A1MAPTLMNA
SCHEMBL2997892 0.84 CA12 (0.56) SMN1; SMN2KDM4EALDH1A1MAPTLMNA
SCHEMBL221653 0.84 MPO (0.57) KDM4EALDH1A1MAPTLMNACYP1A2
SCHEMBL5472654 0.84 RAF1 (0.59) SMN1; SMN2KDM4EALDH1A1MAPTKMT2A
Hydrochloric Acid SCHEMBL28760542 0.82 MAOA (0.56) KDM4EALDH1A1MAPTLMNACYP1A2
SCHEMBL8636928 0.79 TSHR (0.57) LMNACYP1A2CYP3A4MAOAKMT2A
Ethyl Benzoate SCHEMBL28984540 0.77 ESR1 (0.63) SMN1; SMN2ALDH1A1MAPTLMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4013508-A1 [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES Bayer Aktiengesellschaft (DE) 2022-06-22 EP disclosed