Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28465909 | 0.85 | MAPT (0.46) | MAPTALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL11651918 | 0.75 | ALDH1A1 (0.63) | MAPTALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL11651924 | 0.75 | ALDH1A1 (0.63) | MAPTALDH1A1KDM4EHPGDMAPK1 | |
| SCHEMBL5303065 | 0.74 | MAPT (0.49) | MAPTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL5303064 | 0.74 | MAPT (0.49) | MAPTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL1962034 | 0.74 | MIF (0.52) | PLA2G7NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL8259717 | 0.74 | MIF (0.52) | PLA2G7NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL13201409 | 0.74 | MIF (0.52) | PLA2G7NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL8126152 | 0.74 | MIF (0.52) | PLA2G7NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1962036 | 0.74 | MIF (0.52) | PLA2G7NPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110669046-B | Polysubstituted tetrahydro-gamma-carboline derivative with multiple chiral centers and preparation method of stereo diversity of polysubstituted tetrahydro-gamma-carboline derivative | 武汉大学 | 2021-07-06 | — | — | CN | disclosed |
| CN-110669046-A | Polysubstituted tetrahydro-gamma-carboline derivative with multiple chiral centers and preparation method of stereo diversity of polysubstituted tetrahydro-gamma-carboline derivative | 武汉大学 | 2020-01-10 | — | — | CN | disclosed |