Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 6/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
| ▸ | ARG2 | P78540 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9617912 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL10717351 | 0.78 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL4362988 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL28243868 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL14935688 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL31165924 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL19610232 | 0.73 | FDPS (0.47) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL8331176 | 0.73 | FDPS (0.47) | SMN1; SMN2HIF1ACES2CES1CPA1 | |
| SCHEMBL10419786 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2HIF1ACES2CES1FDPS | |
| SCHEMBL28952912 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2HIF1ACES2CES1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110840847-A | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2020-02-28 | — | — | CN | disclosed |