Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2837650 | 0.90 | TP53 (0.57) | TP53LMNAMAPTOPRM1OPRD1 | |
| SCHEMBL2841069 | 0.89 | TP53 (0.49) | TP53LMNAMAPT | |
| SCHEMBL2847041 | 0.86 | TP53 (0.55) | TP53LMNAMAPTOPRM1OPRD1 | |
| SCHEMBL13381938 | 0.86 | TSHR (0.47) | — | |
| SCHEMBL2841776 | 0.85 | LMNA (0.52) | TP53LMNA | |
| SCHEMBL2846520 | 0.85 | TSHR (0.57) | TP53LMNA | |
| SCHEMBL2842414 | 0.83 | TP53 (0.54) | TP53LMNAMAPT | |
| SCHEMBL2841803 | 0.83 | TP53 (0.59) | TP53LMNA | |
| SCHEMBL2846556 | 0.83 | TP53 (0.53) | TP53LMNAMAPT | |
| SCHEMBL2836208 | 0.82 | LMNA (0.53) | TP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | claimed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |