Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2837650 | 0.91 | TP53 (0.57) | TP53LMNA | |
| SCHEMBL2836208 | 0.87 | LMNA (0.53) | TP53LMNA | |
| SCHEMBL2838161 | 0.87 | MAPT (0.61) | TSHRTP53LMNA | |
| SCHEMBL13381505 | 0.86 | TSHR (0.60) | TSHRALDH1A1TP53LMNAKDM4E | |
| SCHEMBL2841776 | 0.86 | LMNA (0.52) | TSHRALDH1A1TP53LMNA | |
| SCHEMBL2841069 | 0.85 | TP53 (0.49) | TSHRTP53LMNA | |
| SCHEMBL2836199 | 0.85 | TP53 (0.52) | TP53LMNA | |
| SCHEMBL2847041 | 0.84 | TP53 (0.55) | TP53LMNA | |
| SCHEMBL2841803 | 0.84 | TP53 (0.59) | TP53LMNA | |
| SCHEMBL2846556 | 0.84 | TP53 (0.53) | TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | claimed |
| WO-2010039911-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |