Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413766 | 0.93 | LMNA (0.61) | LMNAKDM4EL3MBTL1BCAT2NPC1 | |
| SCHEMBL1947849 | 0.93 | LMNA (0.61) | LMNAKDM4EL3MBTL1BCAT2NPC1 | |
| SCHEMBL8366350 | 0.93 | LMNA (0.61) | LMNAKDM4EL3MBTL1BCAT2NPC1 | |
| SCHEMBL24750 | 0.93 | LMNA (0.61) | LMNAKDM4EL3MBTL1BCAT2NPC1 | |
| SCHEMBL30957022 | 0.93 | LMNA (0.61) | LMNAKDM4EL3MBTL1BCAT2NPC1 | |
| Carbamic Acid SCHEMBL3394720 | 0.91 | BCAT2 (0.58) | LMNAKDM4EL3MBTL1BCAT2NPC1 | |
| Carbamic Acid SCHEMBL6362690 | 0.91 | BCAT2 (0.58) | LMNAKDM4EL3MBTL1BCAT2NPC1 | |
| SCHEMBL29588786 | 0.90 | LMNA (0.58) | LMNAKDM4EL3MBTL1BCAT2NPC1 | |
| SCHEMBL18813398 | 0.90 | LMNA (0.58) | LMNAKDM4EL3MBTL1BCAT2NPC1 | |
| SCHEMBL27887405 | 0.90 | LMNA (0.58) | LMNAKDM4EL3MBTL1BCAT2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4082729-A | PROCESS FOR THE PREPARATION OF OXYMETHYLENE POLYMERS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-04-04 | — | — | US | claimed |
| CN-111246873-B | Optimized peptides for targeting human nerves and their use in image guided surgery, diagnosis and therapy delivery | 加利福尼亚大学董事会 | 2024-03-01 | — | — | CN | disclosed |
| EP-2248799-B1 | PROCESS FOR PREPARING 2-(SUBSTITUTED PHENYL)-2-HYDROXY-ETHYL CARBAMATES | SK BIOPHARMACEUTICALS CO LTD (KR) | 2015-05-20 | — | — | EP | disclosed |
| EP-2248799-A1 | Process for preparing 2-(substituted phenyl)-2-hydroxy-ethyl carbamates | Ortho-McNeil Pharmaceutical, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| US-20080097077-A1 | Method For Producing Polyoxymethylenes | BASF AKTIENGESELLSCHAFT (DE) | 2008-04-24 | — | — | US | disclosed |
| EP-1461309-A1 | PROCESS FOR PREPARING 2-(SUBSTITUTED PHENYL) - 2 - HYDROXY-ETHYL CARBAMATES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003053916-A1 | PROCESS FOR PREPARING 2-(SUBSTITUTED PHENYL) - 2 - HYDROXY-ETHYL CARBAMATES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-07-03 | — | — | WO | disclosed |
| US-4082729-A | PROCESS FOR THE PREPARATION OF OXYMETHYLENE POLYMERS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-04-04 | — | — | US | disclosed |