Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.51 |
| ▸ | JAK3 | P52333 | 12/20 | 0.51 |
| ▸ | JAK1 | P23458 | 11/20 | 0.51 |
| ▸ | TYK2 | P29597 | 5/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 3/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552653 | 0.92 | JAK2 (0.44) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL28359023 | 0.90 | JAK2 (0.46) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL29552433 | 0.90 | JAK2 (0.46) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL29922574 | 0.81 | JAK2 (0.48) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL29552560 | 0.80 | CHRNB2 (0.43) | JAK2JAK3JAK1TYK2MELK | |
| SCHEMBL28358968 | 0.80 | ALK (0.42) | JAK2JAK3JAK1TYK2MELK | |
| SCHEMBL29922841 | 0.80 | ALK (0.42) | JAK2JAK3JAK1TYK2MELK | |
| SCHEMBL28362626 | 0.80 | JAK1 (0.49) | JAK2JAK3JAK1TYK2RORC | |
| SCHEMBL29552318 | 0.80 | MAPK6 (0.43) | JAK2JAK3JAK1MELKRORC | |
| SCHEMBL28359197 | 0.80 | DDB1 (0.46) | JAK2JAK3JAK1TYK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |