Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.39 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28358968 | 1.00 | ALK (0.42) | ALKCHRNB2CHRNA4JAK3BTK | |
| SCHEMBL29552560 | 0.90 | CHRNB2 (0.43) | ALKCHRNB2CHRNA4JAK3BTK | |
| SCHEMBL28359023 | 0.90 | JAK2 (0.46) | JAK3MELKGSK3BDYRK1AJAK2 | |
| SCHEMBL29552433 | 0.90 | JAK2 (0.46) | JAK3MELKGSK3BDYRK1AJAK2 | |
| SCHEMBL29552653 | 0.81 | JAK2 (0.44) | ALKJAK3MELKGSK3BDYRK1A | |
| SCHEMBL28362532 | 0.80 | JAK2 (0.51) | JAK3MELKGSK3BDYRK1AJAK2 | |
| SCHEMBL28359197 | 0.79 | DDB1 (0.46) | JAK3BTKJAK2JAK1TYK2 | |
| SCHEMBL28359056 | 0.77 | JAK3 (0.47) | JAK3BTKJAK2JAK1TYK2 | |
| SCHEMBL29922895 | 0.77 | JAK3 (0.47) | JAK3BTKJAK2JAK1TYK2 | |
| SCHEMBL29922874 | 0.76 | JAK2 (0.40) | ALKJAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |