Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.48 |
| ▸ | JAK3 | P52333 | 10/20 | 0.48 |
| ▸ | JAK1 | P23458 | 9/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 3/20 | 0.42 |
| ▸ | FLT4 | P35916 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362532 | 0.81 | JAK2 (0.51) | JAK2JAK3JAK1EGFRMELK | |
| SCHEMBL29922902 | 0.80 | JAK1 (0.41) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL29922756 | 0.77 | JAK2 (0.40) | JAK2JAK3JAK1EGFRLRRK2 | |
| SCHEMBL29922798 | 0.77 | JAK3 (0.52) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL29922883 | 0.77 | TYK2 (0.40) | JAK2JAK3JAK1CLK2TYK2 | |
| SCHEMBL29922888 | 0.76 | MKNK1 (0.37) | JAK2JAK3JAK1LRRK2TYK2 | |
| SCHEMBL29552318 | 0.76 | MAPK6 (0.43) | JAK2JAK3JAK1MELK | |
| SCHEMBL29552653 | 0.74 | JAK2 (0.44) | JAK2JAK3JAK1EGFRMELK | |
| SCHEMBL29922701 | 0.73 | JAK2 (0.41) | JAK2JAK3JAK1LRRK2TYK2 | |
| SCHEMBL29922762 | 0.71 | JAK2 (0.46) | JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |