Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552550 | 0.82 | JAK2 (0.53) | SMN1; SMN2ALDH1A1LMNACCNB2CDK1 | |
| SCHEMBL29552194 | 0.78 | TYK2 (0.51) | SMN1; SMN2ALDH1A1LMNAGAAMAPT | |
| SCHEMBL28362942 | 0.78 | TYK2 (0.51) | SMN1; SMN2ALDH1A1LMNAGAAMAPT | |
| Hydrochloric Acid SCHEMBL29922656 | 0.77 | JAK2 (0.42) | SMN1; SMN2ALDH1A1LMNACCNB2CDK1 | |
| SCHEMBL28362751 | 0.77 | JAK2 (0.62) | SMN1; SMN2ALDH1A1LMNACCNB2CDK1 | |
| Hydrochloric Acid SCHEMBL28855229 | 0.76 | JAK2 (0.62) | SMN1; SMN2ALDH1A1LMNACCNB2CDK1 | |
| SCHEMBL29552289 | 0.64 | JAK2 (0.54) | CCNB2CDK1CCNB1CCNB3MAPT | |
| SCHEMBL29552225 | 0.63 | JAK2 (0.45) | ALDH1A1GAAMAPTNPC1 | |
| SCHEMBL31388289 | 0.62 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1LMNAGAAHTT | |
| SCHEMBL31388283 | 0.62 | ALDH1A1 (0.84) | SMN1; SMN2ALDH1A1LMNAGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-110818641-A | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |