Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362942 | 1.00 | TYK2 (0.51) | TYK2JAK2JAK1JAK3PKM | |
| SCHEMBL29552550 | 0.92 | JAK2 (0.53) | TYK2JAK2JAK1JAK3PKM | |
| SCHEMBL28362751 | 0.91 | JAK2 (0.62) | TYK2JAK2JAK1JAK3PKM | |
| Hydrochloric Acid SCHEMBL28855229 | 0.91 | JAK2 (0.62) | TYK2JAK2JAK1JAK3PKM | |
| SCHEMBL28359048 | 0.84 | TYK2 (0.55) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29551775 | 0.84 | TYK2 (0.55) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29552137 | 0.83 | JAK2 (0.54) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL28359246 | 0.83 | JAK2 (0.54) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29922746 | 0.78 | TYK2 (0.81) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29922630 | 0.78 | TYK2 (0.54) | TYK2JAK2JAK1JAK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |