Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281037 | 0.74 | POLB (0.48) | POLBALDH1A1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL28362428 | 0.73 | ALDH1A1 (0.42) | POLBPTPN1CDC25ACDC25BIDO1 | |
| SCHEMBL4270291 | 0.72 | POLB (0.46) | POLBMAPTLMNA | |
| SCHEMBL4274351 | 0.70 | CYP19A1 (0.47) | POLBALDH1A1LMNAHPGDNPC1 | |
| SCHEMBL4268009 | 0.70 | POLB (0.44) | POLB | |
| SCHEMBL4264715 | 0.69 | POLB (0.43) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL4276459 | 0.69 | LMNA (0.47) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL10811051 | 0.67 | MT-CO2 (0.58) | POLBALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL4273259 | 0.67 | CYP19A1 (0.44) | POLBKMT2AMEN1NR3C1 | |
| SCHEMBL4267433 | 0.66 | POLB (0.41) | POLBALDH1A1MAPK1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110713454-A | Nitro-substituted indole compound and preparation method thereof | 南京工业大学 | 2020-01-21 | — | — | CN | claimed |
| CN-110713454-B | Nitro-substituted indole compound and preparation method thereof | 南京工业大学 | 2022-12-09 | — | — | CN | disclosed |
| CN-110713454-A | Nitro-substituted indole compound and preparation method thereof | 南京工业大学 | 2020-01-21 | — | — | CN | disclosed |