Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212433 | 1.00 | RAB9A (0.41) | RAB9AMEN1KMT2ARECQLNPC1 | |
| SCHEMBL211087 | 0.86 | RAB9A (0.44) | RAB9AMEN1KMT2ARECQLNPC1 | |
| SCHEMBL211088 | 0.86 | RAB9A (0.44) | RAB9AMEN1KMT2ARECQLNPC1 | |
| SCHEMBL2840109 | 0.84 | RAB9A (0.42) | RAB9AMEN1KMT2ARECQLNPC1 | |
| SCHEMBL209967 | 0.81 | CTSK (0.37) | RAB9AALDH1A1MAPK1 | |
| SCHEMBL212323 | 0.81 | MAPT (0.40) | RAB9AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL211144 | 0.79 | RAB9A (0.43) | RAB9AMEN1KMT2ARECQLNPC1 | |
| SCHEMBL211145 | 0.79 | RAB9A (0.43) | RAB9AMEN1KMT2ARECQLNPC1 | |
| SCHEMBL2843927 | 0.78 | ABL1 (0.37) | MAPK1 | |
| SCHEMBL210584 | 0.78 | ABL1 (0.37) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |