Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | PTGFR | P43088 | 4/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP12 | P39900 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210464 | 0.93 | MAPT (0.41) | MAPTSMN1; SMN2TP53PTGFRRORC | |
| SCHEMBL212834 | 0.86 | MAPT (0.41) | MAPTSMN1; SMN2TP53PTGFRRORC | |
| SCHEMBL209967 | 0.81 | CTSK (0.37) | PTGFRFOLH1RAB9A | |
| SCHEMBL212350 | 0.81 | MAOB (0.35) | MAPTFOLH1RAB9A | |
| SCHEMBL214098 | 0.81 | MAPT (0.38) | MAPTSMN1; SMN2TP53PTGFRRORC | |
| SCHEMBL212433 | 0.81 | RAB9A (0.41) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL2836729 | 0.81 | RAB9A (0.41) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL2725003 | 0.80 | MAPT (0.40) | MAPTSMN1; SMN2TP53PTGFRRORC | |
| SCHEMBL212136 | 0.79 | MAPT (0.40) | MAPTSMN1; SMN2TP53RORCTHRB | |
| SCHEMBL2725247 | 0.79 | MAPT (0.41) | MAPTSMN1; SMN2TP53RORCTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |