Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | CCND1 | P24385 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28374900 | 0.93 | KMT2A (0.61) | MTNR1AMTNR1BHPGDMAPTKMT2A | |
| SCHEMBL28370936 | 0.87 | PTGS1 (0.52) | MTNR1AMTNR1BHPGDGAAPOLB | |
| SCHEMBL28375764 | 0.87 | PTGS2 (0.52) | MTNR1AMTNR1BGAAACHERAB9A | |
| SCHEMBL28370672 | 0.86 | PTGS2 (0.68) | MAPTGAAKMT2AMEN1POLB | |
| SCHEMBL31177161 | 0.83 | PTGS2 (0.72) | MTNR1AMTNR1BHPGDMAPK1MAPT | |
| SCHEMBL28370243 | 0.82 | SNCA (0.59) | MTNR1AMTNR1BHPGDGAAPTGS2 | |
| SCHEMBL28376146 | 0.82 | NOTUM (0.57) | MTNR1AMTNR1BHPGDMAPTGAA | |
| SCHEMBL28375771 | 0.82 | HTR6 (0.48) | MTNR1AMTNR1BKMT2AMEN1HCRTR2 | |
| SCHEMBL28374489 | 0.77 | MAPT (0.47) | MTNR1AMTNR1BMAPTPOLBHCRTR2 | |
| SCHEMBL31177165 | 0.76 | PTGS2 (0.74) | MTNR1AMTNR1BHPGDMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106986859-B | Indole derivatives and uses thereof | 广东东阳光药业有限公司 | 2020-02-11 | — | — | CN | disclosed |