SCHEMBL28372992

SCHEMBL28372992

C/C(=C/c1cccc(C#N)c1)C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.59
FBP1 P09467 3/20 0.57
PDCD1 Q15116 1/20 0.55
CD274 Q9NZQ7 1/20 0.55
P4HB P07237 7/20 0.50
KDM4E B2RXH2 1/20 0.46
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
GRIN2D O15399 2/20 0.45
GRIN3B O60391 2/20 0.45
GRIN1 Q05586 2/20 0.45
GRIN2A Q12879 2/20 0.45
GRIN2B Q13224 2/20 0.45
GRIN2C Q14957 2/20 0.45
GRIN3A Q8TCU5 2/20 0.45
GSK3B P49841 2/20 0.45
TBXAS1 P24557 1/20 0.44
SLC9A1 P19634 1/20 0.44
SLC9A3 P48764 1/20 0.44
SLC9A2 Q9UBY0 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3115027 1.00 AKR1C3 (0.59) AKR1C3FBP1PDCD1CD274P4HB
SCHEMBL6981746 1.00 AKR1C3 (0.59) AKR1C3FBP1PDCD1CD274P4HB
SCHEMBL6667243 0.87 FBP1 (0.58) AKR1C3FBP1PDCD1CD274P4HB
SCHEMBL4238897 0.87 FBP1 (0.58) AKR1C3FBP1PDCD1CD274P4HB
SCHEMBL9475839 0.86 PDCD1 (0.51) AKR1C3FBP1PDCD1CD274P4HB
SCHEMBL9475845 0.86 PDCD1 (0.51) AKR1C3FBP1PDCD1CD274P4HB
SCHEMBL31546284 0.84 FBP1 (0.54) FBP1PDCD1CD274P4HBMAOA
SCHEMBL8746678 0.84 AKR1C3 (0.76) AKR1C3KDM4ETBXAS1SLC9A1SLC9A3
SCHEMBL8746676 0.84 AKR1C3 (0.76) AKR1C3KDM4ETBXAS1SLC9A1SLC9A3
Balazipone SCHEMBL636109 0.83 PDCD1 (0.55) FBP1PDCD1CD274P4HBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110997627-A Novel cystobacter amide derivatives 亥姆霍兹感染研究中心有限公司 2020-04-10 CN disclosed